DESIGN, SYNTHESIS, AND IN VITRO EVALUATION OF AZA-PEPTIDE ALDEHYDES AND KETONES AS NOVEL AND SELECTIVE PROTEASE INHIBITORS

Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors

Aza-peptide aldehydes and ketones are a new class of reversible protease inhibitors that are specific for the proteasome and clan CD cysteine proteases.We designed liquid Calcium and synthesised aza-Leu derivatives that were specific for the chymotrypsin-like active site of the proteasome, aza-Asp derivatives that were effective inhibitors of caspa

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Patterns of arterial vascularization in swine hearts

Abstract: This study aimed to characterize the patterns of arterial vascularization in swine hearts.Ninety swine hearts were submitted to the Spalteholz diaphanization technique in order to dissect the coronary arteries.Three types of arterial vascularization patterns were characterized through the behaviorof the rami circumflexus and interventricu

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Teaching press and Literature in the 19th century

The continuous track of the provincial professional press during the last quarter of the 19th century allows us to put together, by means of significant samples of this literary material, the small pieces of history of the school at that period as FLOOR LAMP felt by the main characters, the teachers.The core of the demands, i.e.the delays in paymen

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SOME INFLUENCES OF CHINESE LITERATURE ON VIETNAMESE LITERATURE

The development of Vietnamese literature has been characterized by a critical and selective absorption of the essence of world Kettles literature, with Chinese literature being particularly prominent.The relationship between Chinese and Vietnamese literature is a long-standing cultural interaction that spanned many centuries.Chinese literature has

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Understanding public attitudes to death talk and advance care planning in Northern Ireland using health behaviour change theory: a qualitative study

Abstract Objectives Advance care planning is a key preparatory step in ensuring high-quality palliative and end of life care, and should be considered as a process, beginning with community-level conversations among lay persons.There is, however, indication that death talk among community-dwelling adults is not occurring, and there is a dearth of r

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